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KMID : 0363220160540020119
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Korean Journal of Dermatology
2016 Volume.54 No. 2 p.119 ~ p.124
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Twice-per-week Application of an Adapalene-benzoyl Peroxide Fixed-dose Combination Gel as Maintenance Treatment for Acne Vulgaris in Adults
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Seol Jung-Eun
Lee Won-Kyung
Kang Jung-Nan
Kim Hyo-Jin
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Abstract
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Background: The efficacy and safety of daily maintenance treatment with an adapalene-benzoyl peroxide (adapalene-BPO) fixed-dose combination gel is established in acne vulgaris in adults.
Objective: This study evaluated the efficacy and tolerability of twice-per-week maintenance therapy with an adapalene-BPO combination gel for acne vulgaris in adults.
Methods: All patients applied the adapalene-BPO combination gel once daily during the initial 8 weeks. Subsequently, the patients were randomized into two groups. The maintenance group applied the ointment twice- per-week for 12 weeks of maintenance treatment, while the control group discontinued treatment after the initial 8 weeks active treatment. The changes in the mean numbers of total, inflammatory, and non-inflammatory lesions were assessed.
Results: During maintenance treatment, the changes in the average numbers of total and inflammatory lesions in the maintenance group differed significantly from the control group.
Conclusion: Twice-per-week application of an adapalene-BPO combination gel after active treatment appears to be a good option for the maintenance therapy of acne vulgaris in adults.
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KEYWORD
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Acne vulgaris, Adapalene, Benzoyl peroxide, Maintenance treatment
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